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KMID : 0616620090150010125
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Journal of Soonchunhyang Medical College
2009 Volume.15 No. 1 p.125 ~ p.131
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Clinical Utility of Rapid Influenza Antigen Test
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Song Jun-Hwan
Park Joon-Soo
Nam Hae-Seon
Kim Yong-Bae
Kim Hwi-Jun
Choi Young-Jin
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Abstract
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Rapid diagnosis is essential not only for the initiation of antiviral agents and avoidance of unnecessary use of antibiotic therapy but also for the prevention of nosocomial transmission of influenza virus to patients at high r~sk of influenza related complications. We evaluated the usefulness of the rapid influenza antigen test in a tertiary care hospital laboratory in comparison with reverse transcriptase-polymerase chain reaction (RT-PCR). Clinical specimens taken from 750 patients between February 2007 and May 2008 were nasal swab for rapid test and sputum, nasopharyngeal aspirate and bronchoalveolar wahing for RT-PCR. In 750 patients tested, overall sensitivity of the rapid antigen assay was 47.2% and specificity was 98.6%. Sensitivity for patients lesser than 14 years of ages (55.0%) was significantly higher comparing for patients 14 and more than 14 years of ages (23.1%). Sensitivity and specificity were 16.0% and 100%, respectively, for influenza B. In conclusively, the rapid influenza antigen tests using nasal swab samples were less sensitive for detection of influenza, especially in adult patients and for detection of influenza 8. The use of nasal swab samples for rapid influenza antigen detection methods may be limited in clinical setting.
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KEYWORD
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Influenza, Rapid antigen test, Polymerase chain reaction
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